15. Minerva Med. 2003 Aug;94(4 Suppl 1):27-38

Minerva Med. 2003 Aug;94(4 Suppl 1):27-38.
Migraine during pregnancy and lactation: treatment of the acute attack and non-pharmacological prophylactic strategies.
Allais G(1), Bosio A, Mana O, Airola G, Ciochetto D, Terzi MG, De Lorenzo C, Quirico PE, Benedetto C.
(1)Centro Cefalee della Donna, III Clinica Ostetrico-Ginecologica, Dipartimento di Discipline Ginecologiche e Ostetriche, Università degli Studi di Torino, CSTNF-Centro Studi Terapie Naturali e Fisiche, Torino.

Migraine is a typical “women’s disease”: the fluctuations of sex hormones, in particular estrogens, during woman’s reproductive life show a direct and major influence on migraine course. Even if during pregnancy a high percentage of migraineurs report an improvement of symptomatology, it is still controversial how to manage migraine crises occurring during pregnancy, considering that almost all drugs are partially or totally contraindicated during gestation. The most important drugs employed in acute attack management (triptans, non steroidal anti-inflammatory drugs, analgesics, antiemetics, ergot derivatives and combination products) are reviewed and the indications and contraindications of their use during the 3 trimesters of pregnancy and during lactation, taking into  consideration the indications of the Food and Drug Administration and of the American Academy of Pediatrics, are analysed. Furthermore, the therapeutic effects of the 2 most important non pharmacological therapies used for migraine prophylaxis, biofeedback and acupuncture, are discussed. For this latter therapy, the personal preliminary positive experience using a predetermined formula of acupoints for the combined treatment of migraine and hyperemesis gravidarum is reported.
PMID: 15108609  [PubMed – indexed for MEDLINE]